It will two NFC West division rivals going head to head on Thursday Night Football as the San Francisco 49ers will hit the road to face the St Louis Rams on September 26th in week four pro football action. The 49ers and Rams will get things started from St Louis at 8:25PM Eastern Time and you can watch all of the action live on NFL Network. Check out the updated NFL odds at Bovada sportsbook.
The current Thursday Night Football odds from this game have the road team San Francisco 49ers favored by -3 ½ points with an over under line set at 42 points. Those who bet San Francisco on the money line will lay -175 odds with the take back on the home underdog St Louis Rams at +155 odds.
In their head to head NFC West meeting last year it was St Louis earning the 16-13 home overtime victory against the San Francisco 49ers as a +3 point underdog. The Rams are one of the youngest teams in the NFL and are coming off a 31-7 loss at Dallas. Could have been a look ahead spot for St Louis as they gear up for this National television appearance. St Louis has been rarely featured in prime time games. The Rams have played well at home for Jeff Fisher and has a home victory in week one against the Arizona Cardinals. San Francisco enters play on a two game losing streak. The go into Seattle on Sunday Night Football on two weeks back and get pounded 29-3. Last week the team hosts the Indianapolis Colts and were routed 27-7 as a -10 ½ point betting favorite. The big issue for San Francisco is they are missing key players in their offensive structure. Their three starting wide receivers from last year are missing. Randy Moss retired and both Mario Manningham and Michael Crabtree are injured. On defense the 49ers will be without Aldon Smith on Thursday night and impact pass rusher and linebacker Patrick Willis is bothered by a groin injury. Tight end Vernon Davis is bothered by a hamstring problem and wide out Kyle Williams was limited in practice this week with a rib problem.
With our NFL pro football pick for Thursday Night Football we will play on the home team St Louis Rams +3 ½ points against the injury riddled San Francisco 49ers at the sports books.